Dr Reshma Ramracheya’s breakthrough research gains international recognition. Dr Reshma Ramracheya, Diabetes UK RD Lawrence Research Fellow, along with her team, discovered what puts Type 2 diabetes into remission following bariatric surgery. Her work and her publication, “The Role of PYY in Pancreatic Islet Physiology and Surgical Control of Diabetes”, published in Trends in Endocrinology & Metabolism, have been highlighted in the current issue: Winter 2017 of Diabetes Update, a quarterly publication of Diabetes UK.The study carried out by Dr. Ramracheya and her team revealed the role of a key gut hormone called PYY (peptide tyrosine tyrosine) in restoring normal blood glucose levels in people with Type 2 diabetes following bariatric surgery. Bariatric surgery is known to be effective in bringing Type 2 diabetes into remission for many patients and changes in gut hormone levels have been reported extensively following same. Initially, the researchers considered a gut hormone called GLP-1 as the driving factor of the beneficial effects of bariatric surgery. However, the study demonstrated that the gut hormone PYY, was at higher levels in the blood after the surgery. When they tested this further in the lab using diabetic islets, they found that long-term treatment with PYY could restore the faulty islet function. These findings may lead to the development of therapies that can put Type 2 diabetes into remission without the need for surgery.The research of Dr Ramracheya is being underlined as a vital piece of the puzzle representing exciting step forwards toward the development of drugs that can put Type 2 diabetes into remission.

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